South Carolina Highway 61 (SC 61) is a 67-mile-long (108 km) state highway in the U.S. state of South Carolina. The highway is designated on a north–south direction, but physically travels in an east–west direction, from SC 30 in Charleston to U.S. Route 78 (US 78) near Branchville. The portion of SC 61 from Church Creek Bridge and 10 miles (16 km) north is designated a National Scenic Byway.